Abstract
SummaryThe effect of crosslinking (CXL) on microorganisms and on viral, bacterial, mycotic and acanthamoeba keratitis is summarized. Experimental studies have shown that herpes simplex virus will be reduced on a LogMar scale by 4‐5 lines, of Staphylococcus aureus, Pseudomonas aeruginosa or Candida albicans strains by 1‐2 lines. Previous clinical studies have shown that CXL may heal bacterial, mycotic or even acanthamoeba keratitis, but leads to corneal necrosis in herpetic keratitis. Acanthamoeba cysts also survive CXL therapy. Therefore, CXL may be used as an alternative treatment option in bacterial, mycotic and acanthamoeba keratitis, if they are therapy resistant.
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