Abstract
BackgroundTo evaluate corneal biomechanical properties by the Ocular Response Analyzer (ORA) in non keratoconic patients underwent penetrating keratoplasty (PK).MethodsCorneal hysteresis (CH), corneal resistance factor (CRF), Goldmann- correlated intraocular pressure (IOPg), cornea-compensated IOP (IOPcc) using the ORA, and central graft thickness (CGT) were measured in 30 eyes at least two years after penetrating keratoplasty for non keratoconic indications. IOP using the Goldmann applanation tonometer (GAT) was also obtained after compensation for graft thickness and astigmatism.ResultsThe mean age of patients was 33.1 ± 10.13 years; indications for PK were herpetic corneal scar (53.3%), corneal stromal dystrophy (23.3%), traumatic corneal opacity (10%), chemical corneal opacity (6.7%), and Fuchs endothelial dystrophy (6.7%). Mean CH and CRF were 8.52 ± 1.81 mmHg, and 8.56 ± 1.59 mmHg, respectively. Mean CGT was 532.43 ± 30 μm. Mean IOP GAT, IOPg, and IOPcc were 11.88 ± 3.66, 14.64 ± 4.08, and 17.27 ± 4.60 mmHg, respectively (P < 0.001). No significant association was found between CGT and IOP readings obtained using either the ORA or GAT. There were significant negative association between CH with both IOP GAT and IOPcc, while CRF had significant positive association with IOPg.ConclusionAfter penetrating keratoplasty for non keratoconic patients, graft biomechanics does not return to average values even 2 years after the operation; moreover, intraocular pressure measurement with ORA gives higher values than thickness compensated GAT.
Highlights
To evaluate corneal biomechanical properties by the Ocular Response Analyzer (ORA) in non keratoconic patients underwent penetrating keratoplasty (PK)
This study aims to evaluate the impact of penetrating keratoplasty on corneal biomechanics for non keratoconic patients
The technique for penetrating keratoplasty, carried out by the same surgeon (MSA), was almost identical in all patients with trephine- punch disparity of 0.25 mm, postoperative treatment in the early period included topical moxifloxacin hydrochloride 0.5% and prednisolone acetate 1% eyes drops with gradual tapering over the first year; if corneal opacification originated from herpes simplex virus (HSV), additional oral acyclovir was added with a dose of 400 mg twice daily for at least one year
Summary
To evaluate corneal biomechanical properties by the Ocular Response Analyzer (ORA) in non keratoconic patients underwent penetrating keratoplasty (PK). Using the bidirectional applanation measurements, the ocular response analyzer (ORA; Reichert, Inc., Buffalo, NY) is able to present the four main measurements. Corneal hysteresis (CH) is the difference between the two pressure values, which represents the corneal viscoelastic damping. The mean of these two pressures is the Goldmann-correlated IOP (IOPg). The Corneal-compensated IOP (IOPcc) is a pressure measurement that uses the CH to determine an IOP value that is less affected by corneal properties, such as CCT.
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