Corneal and Lens Autofluorescence in Myopia

Abstract

The purpose of this study was to evaluate the correlation between corneal and lens autofluorescence and the various degrees of myopia. Forty-five eyes of 45 myopic patients (mean age ± SD, 23.8 ± 2.4 years; range, 18 to 27 years) were included. Subjects wearing contact lenses were excluded. After inducing mydriasis, we mea¬sured corneal and lens autofluorescence levels, refractive error, and axial length. A significant correlation was found between refractive error and length of the vitreous cavity. Neither anterior chamber depth nor lens thickness correlated with refrac¬tive error. Refractive error was significantly correlated with corneal and lens autofluorescence levels (r = 0.415, P 0.0005). Corneal and lens autofluorescence levels increased as the axial length increased in myopic eyes. This increase may be related to the breakdown of the blood-ocular barrier that we previ¬ously reported.