Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing

Abstract

The hemorrhage in daily life was a great challenge for the life health. Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat. The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties. In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge. The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension. The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk. Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect. Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF). Moreover, CH/CS4 displayed superior wound healing ability and cytocompatibility. Therefore, the CH/CS4 has high potential application in medical hemostatic field.