Abstract
Corilagin (CLG), a major component of several medicinal plants, can exhibit diverse pharmacological properties including those of anti-cancer, anti-inflammatory, and hepatoprotective qualities. However, there are no prior studies on its potential impact on the epithelial-to-mesenchymal transition (EMT) process. EMT can lead to dissemination of tumor cells into other organs and promote cancer progression. Hence, we aimed to investigate the effect of CLG on EMT and its mechanism(s) of action in tumor cells. We noted that CLG reduced the expression of various epithelial markers and up-regulated the expression of Occludin and E-cadherin in both basal and TGFβ-stimulated tumor cells. CLG treatment also abrogated cellular invasion and migration in colon and prostate carcinoma cells. In addition, CLG effectively attenuated the Wnt/β-catenin signaling cascade in TGFβ-stimulated cells. Overall, our study suggests that CLG may function as and effective modulator of EMT and metastasis in neoplastic cells.
Highlights
Metastasis remains a vital hallmark by which cells originate and spread to distant institutions [1,2]
It is estimated that around 90% of the cancer cells in cancer patients are caused by metastasis [6,7]
The epithelial-to-mesenchymal transition (EMT) process can be triggered by various stimuli, including transforming growth factor-β (TGFβ), epidermal growth factor (EGF), and diverse signaling pathways such as wingless secreted glycoprotein (Wnt)/β-catenin, and have been implicated in cancer regulation [14,15]
Summary
Metastasis remains a vital hallmark by which cells originate and spread to distant institutions [1,2]. It is estimated that around 90% of the cancer cells in cancer patients are caused by metastasis [6,7]. These findings highlight the urgent requirement to further understand mechanisms regulating metastasis and to develop pharmacological strategies to target this process. The EMT process can be triggered by various stimuli, including transforming growth factor-β (TGFβ), epidermal growth factor (EGF), and diverse signaling pathways such as wingless secreted glycoprotein (Wnt)/β-catenin, and have been implicated in cancer regulation [14,15]. Activation of the TGFβ signaling pathway is of major importance for the initiation of EMT [15,16]
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