Abstract
Combining two materials having different functional properties has become a current research area for biomedical applications. The progress of nanoplatforms brings new non-invasive imaging and therapeutic tools for cancer treatment. Here, multifunctional magnetic Fe3O4@ZnO core-shell nanoparticles (Fe3O4@ZnO CSNPs) have been developed by using a soft-chemical approach. Fe3O4@ZnO CSNPs is well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), physical properties measurement system (PPMS), and photoluminescence spectroscopy. XRD and XPS analyses confirm the presence of both Fe3O4 and ZnO phases. TEM micrograph reveals that Fe3O4@ZnO CSNPs are spherical in shape and an average size of 10 nm. Fe3O4@ZnO CSNPs conserve the intrinsic superparamagnetic behavior of its constituent Fe3O4 with a magnetization value of ∼ 31.2 emu/g. These CSNPs exhibit good heating efficacy under the applied AC magnetic field (ACMF). Further, they show a significant reduction in viability of human cervical cancer cells (HeLa) under ACMF and good fluoresecent based cellular imaging capability. Therefore, these results suggested that the multifunctional Fe3O4@ZnO CSNPs could be used as a promising material for image-guided magnetic hyperthermia.
Highlights
Metal oxide nanoparticles (NPs) have received a great deal of attention in biomedical field due to their unique physiochemical properties.1–3 Among the others, Fe3O4 NPs are widely studied for magnetic hyperthermia, drug delivery, magnetic resonance imaging and magnetic separation etc.4–6 The surface of Fe3O4 NPs could be functionalized with various organic and inorganic moieties which help in enhancing their properties.3,6–8 in magnetic hyperthermia, these NPs produce heat on exposure of an alternating magnetic field (ACMF).6,8–10 It raises the temperature of tumor to a therapeutic level (42-45 ○C) and destroys cancer cells.11–13 Further, it provides a localized treatment for the tumor without any significant damage to the surrounding healthy tissue or cells
Fe3O4 NPs of diverse shapes, sizes and magnetic properties are widely explored for magnetic hyperthermia therapy
The phase and structural integrity of Fe3O4 NPs and Fe3O4@ZnO CSNPs were analyzed by X-ray diffraction (XRD) (Fig. 1a)
Summary
Metal oxide nanoparticles (NPs) have received a great deal of attention in biomedical field due to their unique physiochemical properties. Among the others, Fe3O4 NPs are widely studied for magnetic hyperthermia, drug delivery, magnetic resonance imaging and magnetic separation etc. The surface of Fe3O4 NPs could be functionalized with various organic and inorganic moieties which help in enhancing their properties. in magnetic hyperthermia, these NPs produce heat on exposure of an alternating magnetic field (ACMF). It raises the temperature of tumor to a therapeutic level (42-45 ○C) and destroys cancer cells. Further, it provides a localized treatment for the tumor without any significant damage to the surrounding healthy tissue or cells. In magnetic hyperthermia, these NPs produce heat on exposure of an alternating magnetic field (ACMF).. It raises the temperature of tumor to a therapeutic level (42-45 ○C) and destroys cancer cells.. It raises the temperature of tumor to a therapeutic level (42-45 ○C) and destroys cancer cells.11–13 It provides a localized treatment for the tumor without any significant damage to the surrounding healthy tissue or cells. The heating efficiency of MNPs usually reported as specific absorption rate (SAR) which depends on various factors like shape, size, phase composition and magnetic properties of particles as well as their concentration, applied magnetic field strength and frequency.. Fe3O4 NPs of diverse shapes, sizes and magnetic properties are widely explored for magnetic hyperthermia therapy. The heating efficiency of MNPs usually reported as specific absorption rate (SAR) which depends on various factors like shape, size, phase composition and magnetic properties of particles as well as their concentration, applied magnetic field strength and frequency. Fe3O4 NPs of diverse shapes, sizes and magnetic properties are widely explored for magnetic hyperthermia therapy.
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