CO-releasing molecules: avoiding toxicity and exploiting the beneficial effects of CO for the treatment of cardiovascular disorders

Abstract

Future Medicinal ChemistryVol. 5, No. 4 EditorialCO-releasing molecules: avoiding toxicity and exploiting the beneficial effects of CO for the treatment of cardiovascular disordersRoberta Foresti & Roberto MotterliniRoberta ForestiINSERM U955, Equipe 3, Faculty of Medicine, University Paris-Est Creteil, Creteil, FranceSearch for more papers by this author & Roberto Motterlini* Author for correspondenceINSERM U955, Equipe 3, Faculty of Medicine, University Paris-Est Creteil, Creteil, France. Search for more papers by this authorEmail the corresponding author at roberto.motterlini@inserm.frPublished Online:15 Mar 2013https://doi.org/10.4155/fmc.13.10AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: cardiovascular disordersCO-releasing moleculesCO toxicityinnovative therapiestransition metal carbonylsReferences1 Sjostrand T. Endogenous formation of carbon monoxide in man under normal and pathological conditions. Scan. J. Clin. Lab. Invest.1,201–214 (1949).Crossref, CAS, Google Scholar2 Tenhunen R, Marver HS, Schmid R. Microsomal heme oxygenase. Characterization of the enzyme. J. Biol. Chem.244(23),6388–6394 (1969).Crossref, Medline, CAS, Google Scholar3 Kim HP, Ryter SW, Choi AM. CO as a cellular signaling molecule. Annu. Rev. Pharmacol. Toxicol.46,411–449 (2006).Crossref, Medline, CAS, Google Scholar4 Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide from basic science to therapeutic applications. Physiol. Rev.86(2),583–650 (2006).Crossref, Medline, CAS, Google Scholar5 Foresti R, Bani-Hani MG, Motterlini R. Use of carbon monoxide as a therapeutic agent promises and challenges. Intensive Care Med.34,649–658 (2008).Crossref, Medline, CAS, Google Scholar6 Foresti R, Motterlini R. Interaction of carbon monoxide with transition metals evolutionary insights into drug target discovery. Curr. Drug Targets11(11),1595–1604 (2010).Crossref, Medline, CAS, Google Scholar7 Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules characterization of biochemical and vascular activities. Circ. Res.90(2),E17–E24 (2002).Crossref, Medline, CAS, Google Scholar8 Herrmann WA. 100 Years of metal carbonyls. A serendipitous chemical discovery of major scientific and industrial impact. J. Organomet. Chem.383(1–3),21–44 (1990).Crossref, Google Scholar9 Clark JE, Naughton P, Shurey S et al. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ. Res.93(2),E2–E8 (2003).Crossref, Medline, CAS, Google Scholar10 Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat. Rev. Drug Discov.9(9),728–743 (2010).Crossref, Medline, CAS, Google Scholar11 Stein AB, Bolli R, Dawn B et al. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J. Mol. Cell. Cardiol.52(1),228–236 (2012).Crossref, Medline, CAS, Google Scholar12 Chlopicki S, Lomnicka M, Fedorowicz A et al. Inhibition of platelet aggregation by carbon monoxide-releasing molecules (CO-RMs) comparison with NO donors. Naunyn Schmiedebergs Arch. Pharmacol.385(6),641–650 (2012).Crossref, Medline, CAS, Google Scholar13 Desmard M, Foresti R, Morin D et al. Differential antibacterial activity against pseudomonas aeruginosa by carbon monoxide-releasing molecules. Antioxid. Redox. Signal.16(2),153–163 (2011).Crossref, Medline, Google Scholar14 Kramkowski K, Leszczynska A, Mogielnicki A et al. Antithrombotic properties of water-soluble carbon monoxide-releasing molecules. Arterioscler. Thromb. Vasc. Biol.32(9),2149–2157 (2012).Crossref, Medline, CAS, Google Scholar15 Niesel J, Pinto A, Peindy N’dongo HW et al. Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex. Chem. Commun.15,1798–1800 (2008).Crossref, Medline, Google Scholar16 Romanski S, Kraus B, Schatzschneider U, Neudorfl JM, Amslinger S, Schmalz HG Acyloxybutadiene iron tricarbonyl complexes as enzyme-triggered CO-releasing molecules (ET-CORMs). Angew. Chem. Int. Ed. Engl.50(10),2392–2396 (2011).Crossref, Medline, CAS, Google Scholar17 Wang J, Karpus J, Zhao BS, Luo Z, Chen PR, He C. A selective fluorescent probe for carbon monoxide imaging in living cells. Angew. Chem. Int. Ed. Engl.51,9652–9656 (2012).Crossref, Medline, CAS, Google Scholar18 Michel BW, Lippert AR, Chang CJ. A reaction-based fluorescent probe for selective imaging of carbon monoxide in living cells using a palladium-mediated carbonylation. J. Am. Chem. Soc.134,15668–15671 (2012).Crossref, Medline, CAS, Google Scholar19 Finney LA, O’Halloran TV. Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science300(5621),931–936 (2003).Crossref, Medline, CAS, Google Scholar20 Crook SH, Mann BE, Meijer JAHM et al. [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule. Dalton Trans.40(16),4230–4235 (2011).Crossref, Medline, CAS, Google Scholar21 Lo Iacono L, Boczkowski J, Zini R et al. A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the produc-tion of reactive oxygen species. Free Rad. Biol. Med.50(11),1556–1564 (2011).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByRecent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies1 January 2022 | Journal of Materials Chemistry B, Vol. 10, No. 11Ultrasound responsive carbon monoxide releasing micelleUltrasonics Sonochemistry, Vol. 72Iron(I)‐Based Carbonyl Complexes with Bridging Thiolate Ligands as Light‐Triggered CO Releasing Molecules (photoCORMs)16 December 2019 | Zeitschrift für anorganische und allgemeine Chemie, Vol. 646, No. 3Acetoxymethyl Concept for Intracellular Administration of Carbon Monoxide with Mn(CO) 3 -Based PhotoCORMs6 February 2018 | Chemistry - A European Journal, Vol. 24, No. 13Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties19 May 2017 | Cell Death & Differentiation, Vol. 24, No. 7Manganese(I)-Based CORMs with 5-Substituted 3-(2-Pyridyl)Pyrazole Ligands25 January 2017 | Inorganics, Vol. 5, No. 1CORM-EDE1: A Highly Water-Soluble and Nontoxic Manganese-Based photoCORM with a Biogenic Ligand Sphere16 December 2015 | Inorganic Chemistry, Vol. 55, No. 1Carbonyl‐Terpyridyl‐Manganese Complexes: Syntheses, Crystal Structures, and Photo‐Activated Carbon Monoxide Release Properties19 November 2015 | European Journal of Inorganic Chemistry, Vol. 2015, No. 35CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation2 July 2014 | British Journal of Pharmacology, Vol. 172, No. 6Carbon monoxide release properties and molecular structures of phenylthiolatomanganese( i ) carbonyl complexes of the type [(OC) 4 Mn(μ-S-aryl)] 21 January 2015 | Dalton Transactions, Vol. 44, No. 7Visible-Light-Induced CO Release from a Therapeutically Viable Tryptophan-Derived Manganese(I) Carbonyl (TryptoCORM) Exhibiting Potent Inhibition against E. coli3 October 2014 | Chemistry - A European Journal, Vol. 20, No. 46Design and Synthesis of New Hybrid Molecules That Activate the Transcription Factor Nrf2 and Simultaneously Release Carbon Monoxide15 September 2014 | Chemistry - A European Journal, Vol. 20, No. 45Photoactive metal carbonyl complexes as potential agents for targeted CO deliveryJournal of Inorganic Biochemistry, Vol. 133The importance of drug discovery for treatment of cardiovascular diseasesCharles Kennedy15 March 2013 | Future Medicinal Chemistry, Vol. 5, No. 4 Vol. 5, No. 4 Follow us on social media for the latest updates Metrics Downloaded 176 times History Published online 15 March 2013 Published in print March 2013 Information© Future Science LtdKeywordscardiovascular disordersCO-releasing moleculesCO toxicityinnovative therapiestransition metal carbonylsFinancial & competing interests disclosureR Motterlini is co-founder of hemoCORM and has financial interests in the CO-RMs technology. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download