Abstract
Aim: The present study was designed to investigate the coregulatory effects ofmultiple histone modifications (HMs) on gene expression in lung adenocarcinoma (LUAD). Materials & methods: Ten histones forLUAD were analyzed usingChIP-seq and RNA-seq data. An innovative computational method is proposed to quantify the coregulatory effects of multiple HMs on gene expressionto identify strong coregulatory genes and regions. This method was appliedto explore the coregulatory mechanisms of key ferroptosis-related genes in LUAD. Results: Nine strong coregulatory regions were identified for six ferroptosis-related genes with diverse coregulatory patterns (CA9, PGD, CDKN2A, PML, OTUB1 and NFE2L2). Conclusion: This quantitative method could be usedto identify important HMcoregulatory genes and regions that may be epigenetic regulatory targets in cancers.
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