Abstract
In this study, multifunctional hybrid nanoparticles composed of iron platinum (FePt), silica (SiO2), and gold nanoparticles (AuNPs) had been developed for surface-enhanced Raman scattering (SERS) application. Core-shell structure of SiO2 and FePt nanoparticles (FePt@SiO2) was fabricated through sol-gel process and then immobilized gold nanoparticles onto the surface of FePt@SiO2, which displays huge Raman enhancement effect and magnetic separation capability. The resulting core-shell nanoparticles were subject to evaluation by transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX), zeta potential measurement, and X-ray photoelectron spectroscopy (XPS). TEM observation revealed that the particle size of resultant nanoparticles displayed spherical structure with the size ~30 nm and further proved the successful immobilization of Au onto the surface of FePt@SiO2. Zeta potential measurement exhibited the successful reaction between FePt@SiO2 and AuNPs. The rapid SERS detection and identification of small biomolecules (adenine) and microorganisms (gram-positive bacteria, Staphylococcus aureus) was conducted through Raman spectroscopy. In summary, the novel core-shell magnetic nanoparticles could be anticipated to apply in the rapid magnetic separation under the external magnetic field due to the core of the FePt superparamagnetic nanoparticles and label-free SERS bio-sensing of biomolecules and bacteria.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-015-1111-0) contains supplementary material, which is available to authorized users.
Highlights
Rapid, specific, accurate, and sensitive identification and detection of small molecules and pathogenic bacteria are essential toward clinical treatment of infectious diseases
Surface-enhanced Raman scattering (SERS) technique has attracted a lot of attention for more than three decades [5,6,7] because it enhances the Raman signal of the small molecules and or bacteria by several orders of magnitude
Oleic acid and oleic amine protecting the surface of FePt nanoparticles would further generate the hydrophobic characteristic of FePt nanoparticles [31]
Summary
Specific, accurate, and sensitive identification and detection of small molecules and pathogenic bacteria are essential toward clinical treatment of infectious diseases. Conventional protocols for microbial detection, though reliable and gold standard, are time and cost consuming and inconvenient for field situation [1, 2]. In this respect, sensitivity of bacteria into antibiotic depends mostly on measuring the change of its proliferation in response to the drug. Surface-enhanced Raman scattering (SERS) technique has attracted a lot of attention for more than three decades [5,6,7] because it enhances the Raman signal of the small molecules and or bacteria by several orders of magnitude. The enhancements ranging from a factor of Hardiansyah et al Nanoscale Research Letters (2015) 10:412
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