Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization

T Shams,M Parhizkar,U.E Illangakoon,M Orlu,M Edirisinghe

doi:10.1016/j.matdes.2017.09.052

T Shams, M Parhizkar + Show 3 more

Open Access

https://doi.org/10.1016/j.matdes.2017.09.052

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Journal: Materials & Design	Publication Date: Sep 23, 2017
Citations: 28	License type: cc-by

Affiliation: University College London

Abstract

Core/shell microparticles for development of drug delivery systems were prepared using co-axial electrohydrodynamic atomization technique in order to develop fixed dose combined formulations incorporating paracetamol and indomethacin as model drugs. The developed drug delivery systems offered successful co-encapsulation of paracetamol and indomethacin with high drug encapsulation efficiencies of 54% and 69% for paracetamol and indomethacin, respectively. The developed formulations were further characterised with respect to their morphology, drug release profile and possible interactions. In comparison to the release rate of the free indomethacin, the developed formulation resulted in enhanced dissolution rate of indomethacin. This study demonstrates a versatile polymeric platform where multiple drug encapsulation and co-delivery is made possible by utilizing co-axial electrohydrodynamic atomization. The proposed system offered high processing yield of 60–70%, as a single-step platform for preparation of fixed dose formulations for oral drug delivery, particularly in geriatric therapy.

Highlights

IntroductionKnown as FDCs, are essentially two or more active pharmaceutical ingredients formulated in a single dosage form [1]
Fixed dose combination drugs, known as FDCs, are essentially two or more active pharmaceutical ingredients formulated in a single dosage form [1]
The main objective of this work was to co-encapsulate the two drugs into polymeric matrices with the aim to increase the dissolution rate of indomethacin and achieving controlled release of paracetamol, using co-axial electrohydrodynamic atomization

Summary

Introduction

Known as FDCs, are essentially two or more active pharmaceutical ingredients formulated in a single dosage form [1]. These formulations are relatively common for most therapeutic areas and are available for different routes of administration including oral, parenteral and inhalation; among which the oral delivery route is the most common [2]. The potential for drug abuse can be minimised by use of combined drugs, where one would diminish the unintended side effects of the other [9] Incorporation of both short acting and long acting active pharmaceutical ingredients enables coverage of an extended period for therapeutic effect. These are the size of the prepared tablet of the FDC product, disproportionate drug dose combination and different aqueous solubility [1]

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