Abstract
OBJECTIVES:This study aimed to evaluate the clinical and imaging predictive factors for the diagnosis of phyllodes tumors in patients with inconclusive results from core needle biopsy (fibroepithelial lesions).METHODS:We retrospectively analyzed data of patients who underwent surgical excision of breast lesions previously diagnosed as fibroepithelial lesions. Numeric variables were analyzed using the Shapiro-Wilk and t-tests, and categorical variables were analyzed using the chi-square and Fisher’s exact tests. Multivariate logistic regression was performed to calculate odds ratios and detect predictive factors for the diagnosis of PT.RESULTS:A total of 89 biopsy samples were obtained from 77 patients, of which 43 were confirmed as fibroadenomas, 43 as phyllodes tumors, and 3 as other benign, non-fibroepithelial breast lesions. The mean tumor size was 3.61 cm (range, 0.8-10 cm) for phyllodes tumors and 2.4 cm (range, 0.8-7.9 cm) for fibroadenomas. The predictive factor for phyllodes tumor diagnosis was lesion size >3 cm (p<0.001).CONCLUSION:Our data indicate that fibroepithelial lesions of the breast larger than 3 cm are more likely to be phyllodes tumors.
Highlights
Fibroepithelial tumors of the breast are part of a heterogeneous group of biphasic neoplasms resulting from proliferation of both epithelial and stromal components, which include common fibroadenomas (FA) and phyllodes tumors (PT)
This study aimed to evaluate the clinical and sonographic characteristics of patients with inconclusive results in core needle biopsy (CNB) from a breast biopsy database to explore predictive factors for the diagnosis of PT
Patient characteristics and management From the database, we retrieved data on 106 biopsies from 92 patients that were classified as fibroepithelial lesions that could not be further classified as FA or PT between 2002 and 2013
Summary
Fibroepithelial tumors of the breast are part of a heterogeneous group of biphasic neoplasms resulting from proliferation of both epithelial and stromal components, which include common fibroadenomas (FA) and phyllodes tumors (PT).PT is a rare fibroepithelial tumor that is histologically divided into three grades: benign, malignant, or borderline. Only about 10% of these tumors are malignant, even benign tumors are prone to local recurrence and can become very large in size [1] Given their propensity for local recurrence, the standard management of PTs is surgical excision with negative surgical margins [2].
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.