CordyMax extends the lifespan in an aging model: A preliminary report

Abstract

Cordyceps sinensis (Cs) is traditionally believed as an anti‐aging TCM herb. We have reported the anti‐fatigue and endurance enhancement properties of CordyMax (CM), a mycelia fermentation product of Cs, and its benefits in glucose‐lipid‐energy metabolisms. In this study we examined its anti‐aging effects in mice. A total of 192 ICR mice (12 months of age, half males and half females) were randomized into 4 groups, receiving either vehicle or CM at a dose of 0.5, 1.0 or 1.5 g/kg mixed with forage. Calorie intake was monitored twice per week and adjusted carefully to match the calorie intake of controls. Continuous oral CM (72 wks so far) showed: (1) no significant differences in body weight and calorie intake among the groups; (2) compared to controls, the 75% survival time extends 98, 94 and 108 days in the CM groups (0.5, 1.0 and 1.5g/kg, respectively), and the 50% survival time extends 66, 10 and 39 days, respectively. Kaplan‐Meier Survivor analysis showed significantly extended lifespan and reduced risks of death by CM: p=0.049 (Wk36), p=0.036 (Wk40), p=0.059 (Wk48), p=0.004 (Wk60), p=0.027 (Wk 64), p=0.041 (Wk 68) with the best survivor curve for the low dose CM treatment (equivalent to the human dose). This study demonstrates that CM extends the lifespan in mice, while the experiment continues. All the health benefits of CM (anti‐oxidation, the effect in metabolisms and aerobic exercise capacity) support the anti‐aging function of CM.