Cordyceps sinensis Cs‐5 improves memory and learning abilities in a dysmnesia model (684.1)

Abstract

Cordyceps sinensis Cs‐5, a mycelia fermentation product of Cordyceps sinensis (Cs), has shown its health benefits in modulating immune functions and enhancing sexual functions. This study was to examine the effects of Cs‐5 on improving memory and learning abilities in a mouse model with memory impairment. ICR male mice (2 months) were randomized into 3 groups on the basis of the pre‐study swimming latency in water maze test, and received Cs‐5 at a dose of 0.5 or 1.5 g/kg, or vehicle for 60 days. The mice received intraperitoneal injection of Scopolamine Hydrobromide at a dose of 5mg/kg for memory acquisition impairment, and were tested with water maze and step‐through tests to evaluate the memory and learning abilities. Compared to controls, mice received Cs‐5 at a dose of 0.5 g/kg (equivalent to the human recommended dose) showed significantly shortened swimming latency in water maze test, and significantly prolonged step‐through latency in step‐through test (both p=0.03). In conclusion, our results indicate that Cs‐5 is effective on improvement of memory and learning abilities in a mouse model with memory impairment, supporting its potential anti‐aging effect.