Abstract
Objective ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to investigate the concentration of ANGPTL7 in cord blood of preterm infants. Method Singleton infants born in November 2017 to June 2019 in the study hospital were enrolled in the study. Maternal and neonatal clinical data were collected. ANGPTL7 levels in cord blood and serum on the third day after birth were measured by an enzyme-linked immunosorbent assay. Result A total of 182 infants were enrolled in this study. Patients were categorized into two groups by gestational age (102 preterm, 80 full-term). ANGPTL7 levels in preterm infants were significantly higher than that in full-term babies (t = 15.4, P < 0.001). In multiple line regression analysis, ANGPTL7 levels independently correlated with gestational age (β = −0.556, P < 0.001). There is also no correlation between preterm outcomes and ANGPTL7 levels. Cord blood levels of ANGPTL7 were significantly higher than those in serum on the third day after birth (t = 13.88, P < 0.001). Conclusion Cord blood ANGPTL7 levels are higher in preterm infants than full-term babies. The levels are independently influenced by gestational ages and attenuated significantly after birth. The underlying mechanism needs to be further studied.
Highlights
Preterm birth is a worldwide epidemic, and the global incidence of preterm birth is approximately 15 million every year [1]
We found no significant correlation between the cord blood levels of ANGPTL7 in infants and sex, delivery mode, and maternal diabetes
We found that ANGPTL7 levels were negatively correlated with gestational age in preterm infants, but not in term group
Summary
Preterm birth is a worldwide epidemic, and the global incidence of preterm birth is approximately 15 million every year [1]. Premature babies are at high risk for various complications, higher rates of hospital admissions, long-term neurodevelopmental disorders, and behavioral, social-emotional, and learning difficulties in childhood [2]. Among preterm infants, those with a gestational age of less than 33 weeks are at highest risk of mortality and morbidity and cause huge financial and emotional stress on families and society [3]. All proteins are characterized with two domains: an N-terminal coiled-coil domain that mediates homo-oligomerization and a C-terminal fibrinogen-like domain that binds Tie, except for ANGPTL8, which lacks the later domain [4]. The fact that ANGPTLs do not bind to the angiopoietin receptor Tie or Tie makes it possible to distinguish
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