Abstract
We recently reported that antibody-dependent cell-mediated cytotoxicity (ADCC) to Herpes simplex virus (HSV) infected cells could be mediated, not only by K lymphocytes, but by adherent mononuclear cells (MA) isolated from adult human peripheral blood. The MA differ from K lymphocytes in antibody requirement, killing kinetics, and selective inhibition by latex or silica in the Cr51 release assay and are predominantly monocyte-macrophages. Because of the known role of such cells in immunity to several viruses, and since HSV can cause severe neonatal disease, it was of interest to evaluate the function of cord blood MA in ADCC to HSV.Cord blood (CB) from 11 healthy term neonates and maternal blood (MB) from 7 of their postpartum mothers were analyzed for MA activity in an 18 hr. Cr51 ADCC assay against HSV infected Chang liver cells. The magnitude of ADCC produced by MA from CB and MB was not significantly different from that obtained with MA from 8 non-pregnant adult females. Together with our earlier report of cord blood lymphocytes functioning with HSV antibody in ADCC, these data suggest that the use of HSV antibodies for prevention or therapy of neonatal HSV infection requires further consideration.
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