Abstract

A 35-year-old woman, 9 months after a radical mastectomy for carcinoma of the left breast, developed severe dyspnea, with other symptoms and signs of cor pulmonale. She died 3 weeks after the onset of the dyspnea. A chest roentgenogram made shortly before death was negative, and gross examination at autopsy revealed no definite emboli in the pulmonary vessels. The right ventricle, however, showed slight hypertrophy, and on microscopic examination many of the smaller pulmonary arteries and arterioles were found to contain solid clusters of malignant cells. It is suggested that the development of cor pulmonale in patients with malignant tumors may give warning of metastatic activity in time for the physician to institute palliative chemotherapy.

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