Abstract
The utilization of biological resources on the manufacture of nano silver has attracted the interest of researchers to develop an eco-friendly, cost-effective technology in nanomaterials production. In the present study, plant-mediated silver nanoparticles (AgNPs) were synthesized using aqueous leaf extracts of the Copperpod plant, which was well characterized. The ultraviolet-visible spectrophotometric study showed a maximum absorbance peak at 425 nm, and the observation of transmission electron microscopic features revealed that the nanoparticles size ranged between 20 and 70 nm. The synthesized AgNPs were tested for in vitro cytotoxic effects against cancerous cells, such as HepG2, A549 and MCF-7 cells. The findings showed that the IC50 values of AgNPs against cancerous cells viz., HepG2, MCF-7 and A549 cells, were observed to be 69 µg/mL, 62 µg/mL and 53 µg/mL, respectively. In addition, the apoptosis property was analysed using propidium iodide and acridine orange-ethidium bromide via the DNA fragmentation technique. Thus, the outcomes of the current analysis presume that the plant mediated AgNPs obtained from a synthesized Copperpod plant possess significant anti-cancer properties against various cancerous cells.
Highlights
Nanoscience is a division in science that deals with the report on the manipulation of materials at the atomic and molecular level
The results showed that the biogenic AgNPs induced DNA fragmentation of the treated cells (Figure 8) compared to the DNA ladder control cells, which did not show any fragmentation, and this was wellevidenced in our earlier publication [80]
In the current report, the biogenic AgNPs were synthesized employing an aqueous extract of the Copperpod plant
Summary
Nanoscience is a division in science that deals with the report on the manipulation of materials at the atomic and molecular level. The significance of silver and silver-based compounds was recognized much earlier, these materials were not well exploited before, and they were only applied for antimicrobial activity, as antioxidants, for wound healing, for anticancer and anti-inflammatory properties, etc. This suggests that AgNPs are a promising candidate in the field of medical science, due to their vast applications [13,14,15] in the preparation of biopharmaceutical and biocosmetic products [7,12,16,17]
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