Abstract
Starting from readily available -diazo- -keto esters 8 and aromatic primary thioamides 9 and 14, a simple synthesis of 2- aryl 4-substituted thiazole-5-carboxylate derivatives of type 10 and 16 has been accomplished. The method is based on the efficient ca- talysis of CuBr, which promotes the formation of the corresponding carbenoids 11 from diazo derivatives 8. These Cu-carbenoids 11 re- act with the thiocarbonyl group of the primary thioamides to afford presumably intermediates of the general type 12, which by subse- quent cyclocondensation furnish the title thiazole derivatives.
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