Abstract
AbstractCu‐catalyzed enantioselective Cu–B(pin) addition to 1,1‐disubstituted alkenes generating tertiary alkylcopper complexes that contain a quaternary stereogenic center, followed by the protonation of the complexes are presented. The resulting formal hydroboration products are formed in up to 98 % yield and 99:1 enantiomeric ratio. The C–B(pin) moiety can be converted to a variety of useful functional groups. The method is applied to the enantioselective formal synthesis of (R)‐ketoprofen. Detailed stereochemical models for enantioselective induction were elucidated through DFT calculations.
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