Abstract

As an extension on previous research involving the copper(I)-catalyzed domino reductive aldol reaction between methyl acrylate, aldehydes and ketones (Angew. Chem. Int. Ed. 2006, 45, 1292; Org. Lett. 2006, 8, 5943), the authors now describe the application of this methodology in the construction of bicyclic compounds. The procedure can be performed on a 10 mmol scale using only 0.5 mol% catalyst and affords the bicyclic products in good diastereo- and enantio-selectivity.

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