Copper-Catalyzed Direct Amination of Halo(hetero)arenes with Sodium Azide as the Amino Source

Abstract

In the synthesis of primary (hetero)aryl amines through copper-catalysis, the ammonia surrogates or aqueous ammonia nu- cleophilic partners can be replaced by sodium azide. Recent efforts in copper-mediated transformation of (hetero)aryl halides to (het- ero)aryl amines using azide anion as the amino source are discussed in these highlights.