Abstract
AbstractThe direct CH activation path has rationalized the preparation of functionalized molecules by minimizing the number of synthetic steps, and the processes are more atom economic. One such strategy, cross‐dehydrogenative coupling (CDC) reaction is an expedient synthetic protocol for direct CH functionalization including the construction of CC and CX (X = O, S, N, etc.) bonds. In the past years, considerable advancement has been made in the CC bond formation by using different hybrid CH (sp3, sp2, and sp) substrates via the CDC reaction. Particularly, copper‐catalyzed CDC reactions have attracted considerable attention because copper is an abundant, inexpensive, and environmentally benign metal. This article efforts to provide a comprehensive understanding of the development of cross‐dehydrogenative CC coupling via copper catalysis, as well as its mechanism and application in synthetic chemistry.
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