Abstract
An efficient benzylic C–H amidation method was developed through copper-catalyzed C(sp3)−H/N–H cross dehydrogenative coupling between toluene derivatives and N-(8-quinolyl)amides. The 8-quinolyl group directed the activation of N–H bond without influence of quinoline C–H bonds or remote C(sp3)−H bonds. The reaction also showed broad substrate scope with good functional group compatibility, producing various functionalized N-benzyl tertiary amides.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
