Abstract
AbstractHerein, we developed a copper‐catalyzed approach for the remote C(sp3)−H alkynylation of N‐fluoro‐sulfonamides. With Cu(OTf)2 as the catalyst, the carbon radical which generated from nitrogen radical‐mediated 1,5‐hydrogen atom transfer, go through an addition/fragmentation reaction with various acetylene sulfones. A variety of internal alkynes were synthesized in high yield and regioselectivity. Notably, celecoxib‐derived substrate can also gave the corresponding functionalized product in good yield under the standard conditions.magnified image
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