Abstract
Copper that cancer with lysosomal love!
Highlights
There is extensive evidence that chelation of copper and/or iron can inhibit tumour growth in cell culture, animal models and human clinical trials [1]
This property is important in terms of the efficacy of these compounds to induce potent cytotoxic activity and overcome drug resistance, which is a major killer in advanced cancer [6]
The commercialization and clinical trials of these agents has been facilitated by extensive studies demonstrating the broad and potent activity of our first lead agent, di2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), in a variety of tumor cell-types in vitro and in vivo [3,4]
Summary
There is extensive evidence that chelation of copper and/or iron can inhibit tumour growth in cell culture, animal models and human clinical trials [1]. This property is important in terms of the efficacy of these compounds to induce potent cytotoxic activity and overcome drug resistance, which is a major killer in advanced cancer [6].
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