Copper-Powder-Catalyzed Synthesis of Pyrimidines from β-Bromo α,β-Unsaturated Ketones and Amidine Hydrochlorides

Abstract

β-Bromo α,β-unsaturated ketones are coupled and cyclized with amidine hydrochlorides in the presence of a catalytic amount of copper powder along with a base to give the corresponding pyrimidines in good yields.