Abstract
Background: Copper oxide nanoparticles (CuO NPs) exhibit antitumor activity; however, their potential as anantiangiogenesis agent is unknown. Materials & methods: The antiangiogenesis properties of CuO NPs were evaluated in vitro and in vivo and the underlying mechanism was examined using RNAsequencing and metabolomic analyses. Results: CuO NPs inhibited endothelial cell function in vitro. They also mitigated retinal vasculature development and alleviated pathological retinal angiogenesis in vivo. RNAsequencing and metabolomic analyses revealed that CuO NPs disrupt the tricarboxylicacid cycle and induce cuproptosis, which was further supported by evaluating cuproptosis-related metabolites and proteins. Conclusion: CuO NPs may be aneffective antiangiogenic agent for the treatment of retinal angiogenesis.
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