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Abstract
Aims: Copper oxide nanoparticles (CuO NPs), which have potential hazards for organisms and the environment in a number of applications, have emerged as a prominent class of nanomaterials.
 Study Design: This study aimed to investigate the effect of copper oxide nanoparticles in rat liver and kidney tissues.
 Methodology: A total of 20 adult male rats were assigned randomly to 2 groups [1st, control; 2nd, CuO NPs (400 mg/kg body weight/day) intraperitoneally for 4 weeks].
 Results: Current results revealed significant increases in serum ALT, AST, urea, creatinine, potassium ions and liver and kidney tissue damage after CuO NPs administration when compared to control group. Conversely, statistical significant decreases were detected in serum albumin, total proteins, calcium and sodium ions levels in CuO NPs group as compared to control group.
 Conclusion: We can conclude that; CuO NPs induced toxicity and injury in rat liver and kidney tissues.
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