Abstract
Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2(BDC)2(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 μM and 1803 μM (linear range) with good sensitivity (2500 μA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 μM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.
Highlights
At present, the development of glucose biosensors have received more interest in the diagnosis of human blood sugar level, food industry and waste water treatment [1,2]
The electrochemical experiments involving screen printed carbon electrodes (SPCEs) have several advantages such as: (i) no effect of oxygen interference (ii) measurements in micro-volumes of sample solutions are possible and (iii) no need for mechanical polishing of electrode surface [5]. In contrast to these advantages, the use of bare electrodes in the enzyme less electrochemical detection leads to certain drawbacks like poor electron transfer, high over potential and electrode fouling
The surface of SPCEs has been chemically modified by the present-day researchers to sense the desirable analytes [7]
Summary
The development of glucose biosensors have received more interest in the diagnosis of human blood sugar level, food industry and waste water treatment [1,2]. The electrochemical experiments involving SPCEs have several advantages such as: (i) no effect of oxygen interference (ii) measurements in micro-volumes of sample solutions are possible and (iii) no need for mechanical polishing of electrode surface [5]. In contrast to these advantages, the use of bare (unmodified) electrodes in the enzyme less electrochemical detection leads to certain drawbacks like poor electron transfer, high over potential and electrode fouling. The surface of SPCEs has been chemically modified by the present-day researchers to sense the desirable analytes [7] These modified electrodes are chosen to overcome the above shortcomings in the non-enzymatic electrochemical determination of glucose [10,11]
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