Copper Mediated Direct Amination: Synthesis of 1,2,3,15 a‐tetrahydro‐14H‐pyrrolo[1,2‐a]quinazolino[3,2‐c]quinazolin‐14‐onederivatives via 2‐(2‐bromophenyl)quinazolin‐4(3H)‐ones

Abstract

AbstractA convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2‐bromo benzaldehyde, anthranilamide through in situ formation of2‐(2‐bromophenyl)quinazolin‐4(3H)‐one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2‐(2‐bromophenyl)quinazolin‐4(3H)‐one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.