Abstract
γ-Fe2O3@CuFAp nanocatalyst was synthesized and characterized by several methods including XRD, SEM, TEM, ICP, and FT-IR analyses. The γ-Fe2O3@CuFAp has been used as an efficient recyclable magnetic catalyst for synthesis of benzimidazoles. The γ-Fe2O3@CuFAp was conveniently separated from the reaction mixture by an external magnet, and could be reused at least 12 times without any considerable change in catalytic activity.Graphical abstract
Highlights
Benzimidazole is an important structural moiety which is present in many natural and synthetic compounds with a variety of interesting biological activities [1], such as anticancer [2], antiarrhythmic [3], antihistaminic [4], antiulcerative [5], antihypertensives, antiviral, antitumor [1], antibacterial, antifungals [6], anti-inflammatory [7], anticonvulsant, antidiabetic properties [8], and antidepressant [9]
Various methodologies have been used for the synthesis of benzimidazole derivatives, which include conversion of esters using an aluminum reagent [12], the oxidative cyclodehydrogenation of Schiff bases, which is generated from o-phenylenediamine and aldehydes in the presence of several catalysts [13], such as cabalt(II) chloride hexahydrate [14], iodine [15], cetylpyridinium bromide [16], the condensation of o-aryldiamines and aldehyde in refluxing nitrobenzene [17], direct condensation of o-aryldiamines and carboxylic acids [18, 19] or their derivatives [20] in the presence of catalysts, such as polyphosphoric acid [21], ionic liquids [22], p-TsOH [23], SiO2 as solid support [24], microwave irradiation using polyphosphoric acid [25], and intramolecular N-arylations of amidines mediated by potassium hydroxide [26]
As described in the experimental section, Fe3O4 NPs were synthesized by a chemical co-precipitation technique of ferric and ferrous ions in alkali solution
Summary
Benzimidazole is an important structural moiety which is present in many natural and synthetic compounds with a variety of interesting biological activities [1], such as anticancer [2], antiarrhythmic [3], antihistaminic [4], antiulcerative [5], antihypertensives, antiviral, antitumor [1], antibacterial, antifungals [6], anti-inflammatory [7], anticonvulsant, antidiabetic properties [8], and antidepressant [9]. Abstract c-Fe2O3@CuFAp nanocatalyst was synthesized and characterized by several methods including XRD, SEM, TEM, ICP, and FT-IR analyses. The c-Fe2O3@CuFAp has been used as an efficient recyclable magnetic catalyst for synthesis of benzimidazoles. The c-Fe2O3@CuFAp was conveniently separated from the reaction mixture by an external magnet, and could be reused at least 12 times without any considerable change in catalytic activity.
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