Copper(II) ternary complexes with gabapentin and neurotransmitters as antiepileptic drug

Abstract

Novel series of ternary complexes of Cu2+ with antiepileptic drug (Gpn) and neurotransmitters (Gly, Asp, Glu, Ser, GABA and Ade) were synthesized. Surface morphology of the complexes and their chemical composition were studied using elemental analysis, SEM and EDX spectrum. Majority of the complexes were non-electrolytes. Molecular weight and purity was confirmed using GC-MS spectrum. Crystallographic parameters were calculated for the complexes from their XRD data using Expo2014 computer program showing monoclinic and orthorhombic crystal systems with space group P 1 21 1 and P 2 21 21. Crystal structural data, UV–Vis spectra and magnetic moment values indicate distorted square planar and pseudo tetrahedral stereochemistry. IR data reveal that Cu2+ is bonded through COOH of the Gpn and NH2, COO− of the amino acids. ESR spectra showed dx2‒y2 ground state for the Cu2+. TGA, DTG, DTA and the suggested decomposition mechanism confirm the proposed structure of the complexes. The complexes [Cu(Gpn)(Asp)(H2O)].5H2O, [Cu(Gpn)(Ser)Cl] and [Cu(Gpn)(Ade)Cl2].5H2O showed superior anticonvulsant activity compared to gabapentin since they significantly reduced the seizure score compared to PTZ group in male Albino mice. Also, the complex [Cu(Gpn)(Asp)(H2O)].5H2O was the only that markedly prolonged the latency time compared to Gpn group.