Copper(II), palladium(II) and platinum(II) chloride complexes with 5-amino-2- tert-butyltetrazole: Synthesis, characterization and cytotoxicity

Abstract

Complexes CuL 3Cl 2, PdL 2Cl 2 and PtL 2Cl 2, where L is a novel ligand from the series of 2-substituted 5-aminotetrazoles, namely 5-amino-2- tert-butyltetrazole ( 1), have been synthesized by the reaction of metal(II) chlorides with 1 and characterized by IR spectroscopy, thermal and X-ray analyses. The crystallographic structural analysis of these complexes revealed that 1 acts as a monodentate ligand coordinated to the metal via endocyclic N4 atom. Platinum complex demonstrates promising cytotoxicity against human cervical carcinoma cells with IC 50 value average between those of cisplatin and carboplatin.