Abstract
Antifungal activities of MOFs (metal organic frameworks) have been demonstrated in studies, and improvement in efficiency of fungal inactivation is a critical issue in the application of MOFs. In this study, we employed 4,4′-azopyridine (AZPY) in the construction of MOF to improve its antifungal activity. Three-dimensional (3D) copper metal organic framework containing glutarate (Glu) and AZPY (Cu(AZPY)-MOF) was synthesized by a solvothermal reaction. Glutarates bridge Cu2 dinuclear units to form two-dimensional (2D) layers, and these layers are connected by AZPY to form a 3D framework. When spores of two fungi, Candida albicans and Aspergillus niger, were treated with Cu(AZPY)-MOF for one day, number of CFU (colony forming unit) was continuously reduced over treated MOF concentrations, and maximum 2.3 and 2.5 log10CFU reductions (approximately 99% reduction) were observed in C. albicans and A. niger, respectively. Small amounts of CuII ions and AZPY released from Cu(AZPY)-MOF were not critical for fungal inactivation. Our results indicate that the level of antifungal activity of Cu(AZPY)-MOF is greater than that of Cu-MOF without AZPY constructed in our previous study, and intercalation of AZPY is able to improve the antifungal activity of Cu(AZPY)-MOF.
Highlights
Cu(AZPY)-metal organic frameworks (MOFs) has previously been reported on [47], but we newly synthesized it via a solvothermal reaction to investigate its antifungal activities
Glutarates bridge paddle-wheel Cu2 dinuclear units to form 2D layers, and these layers are connected by AZPY to form a 3D framework (Figure S1) while bpe was used for connecting 2D sheets for
Cu(AZPY)-MOF is stable up to 271◦, and it is decomposed with a weight loss of 49.51%, which may attributed to glutarates
Summary
The preparation, characterization and application of metal organic frameworks (MOFs) have attracted considerable attention in the past two decades [1,2,3,4,5,6]. The well-known applications of MOFs are gas sorption and separation [7,8,9,10,11,12,13,14,15], catalysis [16,17,18,19], luminescence sensing [20,21,22,23,24] and biomedical usage [25,26]. MOFs can be used as bioactive framework materials (BioMOFs) for efficient antimicrobial agents [25,26,27,28,29,30,31]. A Co-based MOF (Co-TDM, TDM8− = [(3,5-dicarboxyphenyl)-oxamethyl]methane) is highly effective at inactivating
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