Abstract
Potentiometric, UV–Vis, CD and EPR studies were performed on the copper(II) complexes of oxygen and nitrogen donor ligands (monophosphono dipeptides: 1-( N- l-leucylamino)methylphosphonic acid – Leu–Gly(P), 1-( N- l-leucylamino)valylphosphonic acid – Leu–Val(P)) and a thioether sulfur donor ligands (monophosphono dipeptides: 1- N-(glycyloamino)-2-( S-benzylthio)ethanephosphonic acid – Gly–(Bz)Cys(P), d(+) and Gly–(Bz)Cys(P), d(−)). Complex formation reaction between copper(II) and dipeptides were very similar to each other, [MLH −1] − being the major species in wide pH region. CD spectroscopy, however, was a very sensitive tool for the elucidation of small structural differences among peptide complexes, including the weak interaction in an axial and equatorial position of thioether residues. The complexes of the thioether donors have higher thermodynamic stability constants than the other ones.
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