Copper(II) and Zinc(II) Complexes Derived from N,N’-Bis(4-bromosalicylidene)propane-1,3-diamine: Syntheses, Crystal Structures and Antimicrobial Activity

Yu-Mei Hao

doi:10.17344/acsi.2020.6205

Abstract

A mononuclear copper(II) complex, [CuL] (1), and a phenolato-bridged trinuclear zinc(II) complex, [Zn3Cl2L2(DMF)2] (2), where L is the deprotonated form of N,N'-bis(4-bromosalicylidene)propane-1,3-diamine (H2L), have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, and single crystal X-ray diffraction. The Cu atom in complex 1 is in square planar coordination, while the terminal and central Zn atoms in complex 2 are in square pyramidal and octahedral coordination, respectively. The antibacterial activities of the complexes have been tested on the bacteria Staphylococcus aureus and Escherichia coli, and the yeast Candida parapsilosis.

Highlights

Schiff bases have been extensively used as multi-dentate ligands to construct metal complexes with versatile structures due to their easy formation and strong metal-binding ability.[1]
The complexes 1 and 2 were facile prepared by the reaction of the Schiff base H2L with copper chloride and Scheme 2
Single crystals of the complexes were formed by slow evaporation of the solvent at room temperature

Summary

Introduction

Schiff bases have been extensively used as multi-dentate ligands to construct metal complexes with versatile structures due to their easy formation and strong metal-binding ability.[1]. Most of the Schiff bases and their complexes with transition metals have a broad range of applications in biological and pharmaceutical fields.[2] A number of Schiff bases have been reported for their remarkable biological activities, such as antibacterial, antifungal, antimalarial, anti-proliferative, anti-inflammatory, antiviral and antipyretic activities.[3] Copper(II) and zinc(II) Schiff base complexes have been studied extensively and are considered as excellent alternatives for classic organic antibacterial agents.[4] Despite the presence of considerable research on the antibacterial properties of such complexes, it is still necessary to search for new complexes to find more effective agents as well as to better understand the mechanism of the action of this class of compounds. With an interest in the chemistry of biologically active Schiff bases and their metal complexes, this study aimed to synthesize copper(II) and zinc(II) complexes.

Objectives

Results

Conclusion