Copper(I)‐Catalyzed α‐Acryloyloxylation of Ketones with α,β‐Unsaturated Carboxylic Acids To Form α‐Acryloyloxy Ketones

Abstract

An efficient method for the α‐C–H acryloyloxylation of ketones with α,β‐unsaturated carboxylic acids was developed, using copper(I) as a catalyst. The most concise approach to form α‐acryloyloxy ketones is through direct oxidative coupling at the α‐C(sp3)–H position of ketones. This method gives the products in high yields, and has a wide substrate scope in terms of both ketones and unsaturated carboxylic acids. A copper(I)‐catalyzed reaction mechanism is proposed based on the results of control experiments.