Abstract
AbstractIn the presence of the inexpensive and non‐toxic stoichiometric reductant polymethylhydrosiloxane (PMHS), the chiral copper(II)‐dipyridylphosphine catalyst displayed high efficiency in the stereoselective hydrosilylation of a wide scope of aryl alkyl and heteroaromatic ketones under an air atmosphere and mild conditions in good to excellent ees (up to 97%). With certain amounts of sodium tert‐butoxide and tert‐butyl alcohol as additives, the reaction on a 21‐g substrate scale can be conveniently completed within a few hours even at a substrate‐to‐ligand (S/L) ratio of 50,000.
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