Abstract
The influence of copper deficiency of bovine on immune response was examined. Female Aberdeen Angus heifers were fed a diet containing molibdenum and sulphate for nine months to develop a low copper status. The animals were immunized with live S1119 Brucella abortus. Serum copper concentration and activity of ceruloplasmin were decreased by Cu deficiency. Total level of immunoglobulin G and total complement concentration in serum were impaired by low copper status. Antibody titers to Brucella abortus and proliferation of Concanavalin A and soluble antigen - stimulated peripheral blood mononuclear cells were significantly lower in copper deficient heifers compared to controls. These results show that immune response to a intracellular pathogen may be impaired by copper deficiency.
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