Abstract
Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. 64Cu-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer’s disease amyloid-β (Aβ). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.
Highlights
Metal-containing therapeutic agents comprise a fundamental class of drugs for treating tumors
We summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and various studies of the mechanisms of antitumor and antimicrobial action
Many metal-containing drugs based on gold, ruthenium, gallium, titanium, and iron are in preclinical and clinical trials phases I and II [1], cisplatin and second- and third-generation platinum coordination compounds are still the most effective antitumor agents used in clinical practice [2]
Summary
Metal-containing therapeutic agents comprise a fundamental class of drugs for treating tumors. A number of copper/Disulfiram-based drug combinations are in recruiting clinical trials as inexpensive and highly effective antitumor agents for metastatic breast cancer therapy and as diagnostic tools [28]. Their clinical success has triggered the development of delivery and controlled release systems for copper coordination compounds, as well as a search for novel copper-containing anticancer agents [29,30]. A brief and clear summary of promising in vivo anticancer activity of this type of drugs, along with relevant and current clinical trials was reported by Tabti et al [31], but rapid development of copper-based therapy has caused rapid changes in clinical data. This review could be useful to researchers engaged in medicinal application of copper-containing agents, affecting various uses of copper coordination compounds such as anticancer, antituberculosis, antimicrobial, anti-inflammatory, antibacterial agents, as well as PET-imaging agents for the diagnosis of malignant neoplasms and Alzheimer’s disease
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