Abstract
Two new Cu(II) Schiff base complexes were synthesized and characterized. The corresponding NO type bidentate Schiff base ligands were synthesized from the condensation of 2,5-dimethylaniline (HL1) or 3,5-dimethylaniline (HL2) with 4-acetyl-3-methyl-1-phenyl-5-pyrazolone. Another bidentate Schiff base ligand (HL3) was also synthesized from the condensation of Prop-2-en-1-amine (allylamine) with 4-acetyl-3-methyl-1-phenyl-5-pyrazolone but all attempts to synthesize the corresponding Schiff base complex failed. The ligands and complexes were characterized by general spectroscopic techniques including 1HNMR, IR, UV–Vis spectroscopy as well as elemental analysis. Crystal structure of one of the complexes, [Cu(L1)2] was determined. Antibacterial potential of these ligands and complexes were tested against four bacteria, namely Escherichia coli (G−), Pseudomonas aeruginosa (G−), Staphylococcus aureus (G+) and Bacillus subtilis (G+). The ligands and complexes showed considerable antibacterial activity against both gram-positive and gram-negative bacteria. The ligands almost showed higher antibacterial activity than the corresponding complexes.
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