Copper chromite nanoparticles as an efficient and recyclable catalyst for facile synthesis of 4,4'-(arylmethanediyl)bis(3-methyl-1H-pyrazol-5-ol) derivatives

Abstract

In this study, pure spinel nanoparticles of copper chromite (CuCr2O4) were synthesized by coprecipitation method. These nanoparticles were characterized by X-ray diffraction, scanning electron microscopy, and FTIR. CuCr2O4 nanoparticles were found to be an efficient catalyst for the synthesis of 4,4'-(arylmethanediyl)bis(3-methyl-1H-pyrazol-5-ols) via pseudo-five-component reaction of aldehydes, hydrazine hydrate, and ethyl acetoacetate. The present methodology offers several advantages such as excellent yields, simple procedure, and mild conditions. The catalyst can be reused at least five times without any obvious change in its catalytic activity.