Abstract
A three-component cascade cyclization catalyzed by copper was employed to synthesize quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as starting materials. Sulfur atoms play an important role in controlling the regioselectivity, by stabilizing the high-valent vinyl copper intermediate. Meanwhile, the sulfide group at position 4 of quinoline could be further utilized as a transformable group for ipso-transformation and as a directing group for C-H functionalization, affording various multifunctional quinoline derivatives.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
