Abstract
A concise synthesis of pyrroloquinolinones is reported from the reaction of isocyanides and N-(o-haloaryl)propiolamides under copper-catalyzed conditions. A mechanism in which a copper-catalyzed [3+2] cycloaddition to form an organocopper species followed by an intramolecular C-C coupling involving N-(o-iodoaryl)propiolamides is proposed. Good functional group compatibility was observed; however, for X = Br the reaction efficiency was greatly reduced.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
