Abstract
Alumina supported copper was found to be most selective for the synthesis of cyclic amines from the corresponding amino-alcohols. Cyclizations were performed in a continuous fixed-bed reactor at 200 – 210 °C in the presence of hydrogen. Cycloamination of 5-amino-pentanol-(1) leads to piperidine, cycloamination of 4-amino-butanol-(1) to pyrrolidine, and cycloamination of 2-(o-aminophenyl)-ethanol to indole. Selectivities obtained were higher than 90%. Cycloamination of N-(2-hydroxy-ethyl)-ethylenediamine to piperazine was also very selective (95%); however, deactivation of the catalyst was observed.
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