Abstract
A novel copper-catalyzed sp3-carbon radical/carbamoyl radical cross-coupling protocol for the construction of C(sp3)-C(O) bond is described. This provides a straightforward method for synthesis of 2-carbamoyl-1,3-dicarbonyl compounds in good to excellent yields under mild conditions. Mechanistic studies confirms the generation of both carbamoyl and C(sp3)-centered radicals directly from oxidation of C(sp3)-H bond of formamides and 1,3-dicarbonyl compounds, respectively.
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