Copper-Catalyzed Remote C(sp3)-H Phosphorothiolation of Sulfonamides and Carboxamides in a Multicomponent Reaction.

Abstract

The catalytic C(sp3)-H functionalization is highly desirable yet challenging in organic synthesis. Incorporation of the SP(O)(OR)2 group through C(sp3)-H functionalization remains unexplored. We herein report an unprecedented protocol for phosphorothiolation of primary and secondary C(sp3)-H via a multicomponent reaction with N-fluoro-substituted amides, elemental sulfur, and P(O)H compounds involving a sequence of amidyl radical generation, 1,5-HAT, and a Cu-catalyzed cross coupling of the resulting carbon radical with (RO)2P(O)SH (generated in situ).