Abstract
AbstractThe cycloisomerization of readily available 2‐alkynylbenzamides has been conveniently carried out with CuCl2 as catalyst under basic conditions in 1‐ethyl‐3‐methylimidazolium ethyl sulfate (EmimEtSO4) as an unconventional solvent. The process leads to (Z)‐3‐alkylideneisoindolin‐1‐ones in a chemo‐, regio‐, and stereoselective manner. The catalyst/solvent/base system could be recycled several times without appreciable loss of activity. The structures of representative products, that are, (Z)‐3‐benzylidene‐2‐phenylisoindolin‐1‐one and (Z)‐3‐pentylidene‐2‐phenylisoindolin‐1‐one, have been confirmed by X‐ray diffraction analysis, and DFT (density functional theory) calculations have been carried out to clarify the roles exerted by the base and CuCl2 in favoring the reaction course leading to (Z)‐3‐alkylideneisoindolinones.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
