Abstract
A copper-catalyzed oxidative dehydrogenative reaction of quinoline N-oxides with donor-acceptor cyclopropanes has been demonstrated to construct C2-alkylated quinolines containing a γ-keto diester motif. The use of molecular oxygen as an oxidant, excellent site-selectivity, and good functional group tolerance are the important features in this process. The preliminary mechanistic studies demonstrate that the catalyst plays a dual role as a Lewis acid and a redox catalyst.
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