Copper‐Catalyzed Oxidative Carboamination of Maleimides with Amines and α‐Bromo Carboxylates

Abstract

AbstractA copper‐catalyzed oxidative carboamination of maleimides with alkyl amines and α‐bromo carboxylates is described. These multicomponent reactions show good functional group compatibility and are suitable for the late‐stage modification of a series of neuroprotective agents, providing a direct path for the library synthesis of 3‐carbo‐4‐amino maleimides. The initial copper‐catalyzed oxidative amination of maleimides with amines to form enamines intermediate, followed by copper‐catalyzed radical alkylation with α‐bromo carboxylate compounds, triggers a relayed catalytic reaction to achieve the carboamination process.magnified image